← Back to Search

Procedure

Ultrasound Group for Long COVID Syndrome (LOCUS Trial)

N/A
Waitlist Available
Led By Farha Ikramuddin, M.D.
Research Sponsored by SecondWave Systems Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-65 years at the time of enrollment
Symptoms present for 12 or more weeks that are independent prior to SARS-CoV-2 infection including fatigue and one or more of: Myalgia or general aches/pains, Joint pain, Dizziness/lightheadedness, Cognitive dysfunction (brain fog)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

LOCUS Trial Summary

This trial aims to test the safety and effectiveness of using ultrasound stimulation on the spleen as a treatment for Long COVID. The study will measure the activity of the disease before, during, and after

Who is the study for?
This trial is for individuals experiencing Long COVID symptoms. Participants should be able to undergo daily spleen-directed ultrasound stimulation for 8 weeks. Specific eligibility criteria are not provided, but typically participants would need to meet certain health conditions and agree to the study's procedures.Check my eligibility
What is being tested?
The trial is testing whether stimulating the spleen with ultrasound can help people with Long COVID. Over an 8-week period, researchers will monitor disease activity and molecular changes related to Long COVID before, during, and after treatment.See study design
What are the potential side effects?
While specific side effects of spleen-directed ultrasound are not listed, the study aims to track any adverse events throughout its duration to ensure safety.

LOCUS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 65 years old.
Select...
I have had fatigue and other symptoms like muscle pain or brain fog for over 12 weeks since recovering from COVID-19.

LOCUS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Within-arm change in the endurance shuttle walk test (ESWT) from baseline to the completion of an up-to 8-week intervention period.
Secondary outcome measures
Track adverse events throughout the study to assess the safety of the ultrasound intervention.
Within-arm change in the Chalder fatigue scale (CFQ-11; Likert score) from baseline to the completion of an up-to 8-week intervention period.

LOCUS Trial Design

1Treatment groups
Experimental Treatment
Group I: Ultrasound GroupExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Splenic Ultrasound
2021
N/A
~80

Find a Location

Who is running the clinical trial?

SecondWave Systems Inc.Lead Sponsor
3 Previous Clinical Trials
112 Total Patients Enrolled
University of MinnesotaOTHER
1,388 Previous Clinical Trials
1,552,812 Total Patients Enrolled
MCDC (United States Department of Defense)UNKNOWN
1 Previous Clinical Trials
58 Total Patients Enrolled
~0 spots leftby Jul 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top