← Back to Search

Exercise Training for Parkinson's Disease

N/A
Recruiting
Led By Amy Amara, MD, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Montreal Cognitive Assessment (MoCA) score ≥ 18 and <26 (performed at screening visit)
On stable medications for at least 4 weeks prior to study entry without expecting to change medications for the duration of the study
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to twelve week and change from twelve weeks to 24 weeks.
Awards & highlights

Study Summary

This trial looks at whether exercise can help improve cognition in people with Parkinson's, and whether slow wave sleep is a marker of how well someone will respond to exercise rehabilitation.

Who is the study for?
This trial is for people aged 45 or older with Parkinson's Disease (PD) who can walk without help and have mild to moderate symptoms. They should be on stable PD meds, not expecting changes during the study, and score between 18-26 on a cognitive test. Those with serious heart conditions, other types of Parkinsonism, deep brain stimulation implants, untreated sleep disorders or those already doing regular exercise cannot join.Check my eligibility
What is being tested?
The study tests how different exercise programs—Endurance Training (ET), Delayed Exercise Training (DE), Progressive Resistance Training (PRT)—affect thinking skills in PD patients and if Slow Wave Sleep can indicate improvement from these exercises.See study design
What are the potential side effects?
While specific side effects are not listed for this type of physical activity intervention, general risks may include muscle soreness, fatigue, joint pain or injury. The safety will be monitored closely given the participants' condition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My cognitive test score is between 18 and 25.
Select...
My medications have been the same for the last 4 weeks and won't change during the study.
Select...
My Parkinson's disease is at a moderate stage.
Select...
I have Parkinson's disease diagnosed with slow movements and possibly tremor, stiffness, or balance issues.
Select...
I am 45 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to twelve weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to twelve weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Cognition in Stroop inhibition
Secondary outcome measures
Change in slow wave sleep (SWS)

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Exercise GroupActive Control2 Interventions
PD participants randomized to progressive resistance training PRT) will have 12 weeks of supervised PRT 3 times per week. After the 1st 12 weeks, responders to PRT (increase in slow wave sleep) will continue PRT for an additional 12 weeks, non-responders to PRT will transition to endurance training (ET).
Group II: Delayed Exercise GroupPlacebo Group2 Interventions
PD participants randomized to the delayed exercise control group will not exercise for the 1st 12 weeks of the study. After the 1st 12 weeks, participants in the delayed exercise group will transition to PRT for the 2nd 12 weeks.

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,594 Previous Clinical Trials
2,282,975 Total Patients Enrolled
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,977 Previous Clinical Trials
2,680,677 Total Patients Enrolled
University of Colorado, DenverLead Sponsor
1,749 Previous Clinical Trials
2,163,940 Total Patients Enrolled

Media Library

Delayed Exercise Training (DE) Clinical Trial Eligibility Overview. Trial Name: NCT04796506 — N/A
Parkinson's Disease Research Study Groups: Exercise Group, Delayed Exercise Group
Parkinson's Disease Clinical Trial 2023: Delayed Exercise Training (DE) Highlights & Side Effects. Trial Name: NCT04796506 — N/A
Delayed Exercise Training (DE) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04796506 — N/A
~47 spots leftby Mar 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top