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Dietary Supplement

High-salt diet for Obesity

N/A
Waitlist Available
Led By Rachelle Crescenzi, PhD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at baseline and each of 3 study visits occurring about every 7 days, to be completed in no less than 21 days.
Awards & highlights

Study Summary

This trial will compare how people react to salt in their diet versus how much salt their bodies actually absorb.

Eligible Conditions
  • Obesity
  • Cardiovascular Risk
  • Hypernatremia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~following completion of all dietary supplements and washout, in no less than 21 days.
This trial's timeline: 3 weeks for screening, Varies for treatment, and following completion of all dietary supplements and washout, in no less than 21 days. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Salt-sensitive blood pressure after low salt diet
Secondary outcome measures
Fat fraction of the legs
Kidney blood perfusion rate
Lymphatic stasis of the legs
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Low- then high-salt dietExperimental Treatment2 Interventions
10 subjects will be enrolled and each will undergo study procedures at 4 separate visits. Subjects will be randomly assigned to this study arm, differing in the order of low and high salt diets. After a baseline visit to include a noninvasive MRI scan, the subject will begin this study diet: low-salt diet, then washout consisting of the subject's typical diet, then high-salt diet. Each dietary or washout period lasts for 7 days, and study visits will occur after each period.
Group II: High- then low-salt dietExperimental Treatment2 Interventions
10 subjects will be enrolled and each will undergo study procedures at 4 separate visits. Subjects will be randomly assigned to this study arm, differing in the order of low and high salt diets. After a baseline visit to include a noninvasive MRI scan, the subject will begin this study diet: high-salt diet, then washout consisting of the subject's typical diet, then low-salt diet. Each dietary or washout period lasts for 7 days, and study visits will occur after each period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Low-salt diet
2019
N/A
~20
High-salt diet
2019
N/A
~20

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
866 Previous Clinical Trials
672,656 Total Patients Enrolled
35 Trials studying Obesity
6,862 Patients Enrolled for Obesity
Rachelle Crescenzi, PhDPrincipal Investigator - Department of Radiology, Vanderbilt University Medical Center
Vanderbilt University Medical Center
2 Previous Clinical Trials
185 Total Patients Enrolled
~3 spots leftby Jun 2025
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