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Speech and Language Therapy for Primary Progressive Aphasia

N/A
Waitlist Available
Led By Maya L Henry, PhD
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-treatment to post-treatment (approximately 6 weeks after treatment onset) and follow-ups at 3 months post-treatment, 6 months post-treatment, and 12 months post-treatment
Awards & highlights

Study Summary

This trial is studying whether a treatment designed to improve speech and language function can also help to slow the decline of primary progressive aphasia (PPA).

Who is the study for?
This trial is for adults with Primary Progressive Aphasia (PPA) who can pass a basic mental state exam. It's not suitable for those with major vision or hearing issues, other cognitive-linguistic affecting conditions, or significant non-speech-language impairments.Check my eligibility
What is being tested?
The study tests two speech and language therapies: Video-Implemented Script Training (VISTA) and Lexical Retrieval Training (LRT), aiming to improve communication in PPA patients. It also looks at how these treatments might change the disease's progression over a year.See study design
What are the potential side effects?
Since the interventions are behavioral therapies focusing on improving speech and language skills, there are no direct medical side effects like you'd expect from medication; however, participants may experience fatigue or frustration during therapy sessions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-treatment to post-treatment (approximately 6 weeks after treatment onset) and follow-ups at 3 months post-treatment, 6 months post-treatment, and 12 months post-treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-treatment to post-treatment (approximately 6 weeks after treatment onset) and follow-ups at 3 months post-treatment, 6 months post-treatment, and 12 months post-treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in script production accuracy
Change in spoken naming of target items
Secondary outcome measures
Change on Boston Naming Test
Change on Communicative Effectiveness Index
Change on Mini Mental State Exam
+2 more
Other outcome measures
Post-treatment Communication Survey

Trial Design

2Treatment groups
Experimental Treatment
Group I: Script TrainingExperimental Treatment1 Intervention
Group II: Lexical Retrieval TreatmentExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
356 Previous Clinical Trials
81,419 Total Patients Enrolled
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
331 Previous Clinical Trials
178,427 Total Patients Enrolled
University of California, San FranciscoOTHER
2,517 Previous Clinical Trials
15,240,969 Total Patients Enrolled

Media Library

Lexical Retrieval Training (LRT) Clinical Trial Eligibility Overview. Trial Name: NCT04881617 — N/A
Nonfluent Aphasia Research Study Groups: Lexical Retrieval Treatment, Script Training
Nonfluent Aphasia Clinical Trial 2023: Lexical Retrieval Training (LRT) Highlights & Side Effects. Trial Name: NCT04881617 — N/A
Lexical Retrieval Training (LRT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04881617 — N/A
~1 spots leftby Jun 2024
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