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Forced Desynchrony for High Blood Pressure
N/A
Recruiting
Led By Steven A Shea, PhD
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Free of all prescription and non-prescription drugs (including caffeine, nicotine, alcohol and herbal medications)
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7-day lab stay
Awards & highlights
Study Summary
This trial will help determine if different therapies for hypertension are effective for black adults based on the root cause of their hypertension.
Who is the study for?
This trial is for self-identified Black or White adults who are either 'normotensive' with blood pressure under 140/90 mmHg, or have stage 1 hypertension with systolic BP between 140 and 160 mmHg or diastolic BP between 90 and 100 mmHg. Participants should not be on any medication (including caffeine and alcohol), must not smoke, do night shifts, or have traveled across time zones recently. They also shouldn't have severe health issues like renal disease.Check my eligibility
What is being tested?
The study investigates how sleep, circadian rhythms, and behaviors contribute to non-dipping blood pressure profiles in Black adults compared to White adults. It aims to understand if race influences the best treatment for hypertension by examining these different factors.See study design
What are the potential side effects?
Since this trial involves behavioral interventions rather than medications, there may be minimal side effects related directly to the intervention itself. However, changes in sleep patterns could potentially cause temporary fatigue or stress.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am not taking any prescription, over-the-counter drugs, or substances like caffeine or alcohol.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 7-day lab stay
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7-day lab stay
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Blood pressure
Heart rate variability
Secondary outcome measures
24-hr ambulatory blood pressure
beat-by-beat blood pressure
flow mediated dilation
+6 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Forced DesynchronyExperimental Treatment1 Intervention
All participants will undergo a forced desynchrony protocol.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Forced Desynchrony
2014
N/A
~40
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Who is running the clinical trial?
Oregon Health and Science UniversityLead Sponsor
979 Previous Clinical Trials
7,386,409 Total Patients Enrolled
6 Trials studying Cardiovascular Risk
1,630 Patients Enrolled for Cardiovascular Risk
Steven A Shea, PhDPrincipal InvestigatorOre
3 Previous Clinical Trials
73 Total Patients Enrolled
1 Trials studying Cardiovascular Risk
16 Patients Enrolled for Cardiovascular Risk
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have smoked in the past year.I have been diagnosed with moderate to severe sleep apnea.I have no severe health issues except possibly mild high blood pressure or serious kidney disease.I am taking medication for high blood pressure.You have traveled across more than three time zones in the three months before the study.I am not taking any prescription, over-the-counter drugs, or substances like caffeine or alcohol.You have worked night shifts or rotating shifts regularly for the three months before the study.You have had serious mental health conditions or substance abuse issues in the past.Your blood pressure is higher than 160 over 100.Your blood pressure should be normal or slightly high, but not too high.
Research Study Groups:
This trial has the following groups:- Group 1: Forced Desynchrony
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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