Your session is about to expire
← Back to Search
Engage & Connect Therapy for Depression
N/A
Recruiting
Led By Nili Solomonov, PhD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Diagnosis of unipolar major depressive disorder without psychotic features, determined by the SCID
Mini Mental Status Exam (MMSE) ≤ 1 SD below the mean score for patient's age and education
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, mid-treatment (week 5) and post treatment (week 9)
Awards & highlights
Study Summary
This trial will use fMRI to study how people with depression react to social rewards, in order to help develop a more personalized form of treatment.
Who is the study for?
This trial is for individuals aged 50-85 with major depressive disorder, a MADRS score ≥ 20, and stable mental status. They must be on a steady antidepressant dose or off medication for 8 weeks and able to consent. Excluded are those with suicidal intent, other psychiatric/neurological disorders, certain medical conditions, or contraindications to MRI scanning.Check my eligibility
What is being tested?
'Engage & Connect' psychotherapy aims at activating the brain's reward system during social interactions in older adults with depression. The study will use neuroimaging and computational modeling to predict who benefits most from this therapy compared to standard Symptom Review and Psychoeducation (SRP).See study design
What are the potential side effects?
Since this trial involves psychotherapy rather than medication, side effects may include emotional discomfort or distress due to discussing personal issues during therapy sessions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have been diagnosed with major depression without psychosis.
Select...
My mental function test score is slightly below average for my age and education.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, mid-treatment (week 5) and post treatment (week 9)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, mid-treatment (week 5) and post treatment (week 9)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Resting State fMRI Connectivity of the Positive Valence System
Secondary outcome measures
Change in Behavioral Activation for Depression Scale (BADS)
Change in Montgomery Asberg Depression Rating Scale (MADRS)
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: "Engage & Connect" PsychotherapyExperimental Treatment1 Intervention
"Engage & Connect", a modified adapted version of "Engage". Its principal intervention is "social reward exposure" - facilitating engagement in rewarding and meaningful social activities with significant others. In "Engage-S" therapy, individuals with depression work with a therapist to develop "action plans" to pursue rewarding social activities of their choice.
Group II: Symptom Review and Psychoeducation (SRP)Active Control1 Intervention
In this intervention, the therapist will review the participant's symptoms and provide literature-based clinical explanations and clarifications about the symptoms, the course, and the causes of depression. In SRP, the therapist reviews the depressed individual's symptoms, and level of information on depression, identifies misconceptions, and guides selection of educational material which could benefit the patient.
Find a Location
Who is running the clinical trial?
Weill Medical College of Cornell UniversityLead Sponsor
1,059 Previous Clinical Trials
1,316,083 Total Patients Enrolled
66 Trials studying Depression
16,338 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,798 Previous Clinical Trials
2,660,858 Total Patients Enrolled
672 Trials studying Depression
253,283 Patients Enrolled for Depression
Nili Solomonov, PhDPrincipal InvestigatorWeill Medical College of Cornell University
2 Previous Clinical Trials
188 Total Patients Enrolled
2 Trials studying Depression
188 Patients Enrolled for Depression
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been on a stable dose of antidepressants for 8 weeks and don't plan to change it.I can sign and understand the consent form for this study.I have been diagnosed with major depression without psychosis.I only use up to 0.5 mg of lorazepam daily, no more than 7 times a week.I've been on the same dose of antidepressants for 8 weeks and don't plan to change it.I am between 50 and 85 years old.My mental function test score is slightly below average for my age and education.I can sign and understand the consent form for the study.The Montgomery-Åsberg Depression Rating Scale (MADRS) score is ≥ 20.
Research Study Groups:
This trial has the following groups:- Group 1: "Engage & Connect" Psychotherapy
- Group 2: Symptom Review and Psychoeducation (SRP)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Share this study with friends
Copy Link
Messenger