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Anesthetic

Spinal anesthesia group for Dementia

N/A
Waitlist Available
Led By George Djaiani, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years
Awards & highlights

Study Summary

This trialinvestigates if elderly patients are less likely to develop dementia/Alzheimers if they have spinal (awake/sedated) vs. inhalational (asleep) anesthesia for surgery, taking into account risk factors.

Eligible Conditions
  • Dementia
  • Alzheimer's Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Assessing the incidence of early dementia

Trial Design

2Treatment groups
Active Control
Group I: Spinal anesthesia groupActive Control4 Interventions
Spinal anesthesia group will receive bupivacaine 10-15mg anesthesia according to the standard practice. Supplemental sedation with intravenous anesthetics (midazolam/propofol) will be optional.
Group II: General anesthesia groupActive Control4 Interventions
Induction of anesthesia will be achieved with propofol 1.5-2mg/kg and fentanyl 1-3g/kg. Anesthesia will be maintained with inhalational anesthesia (isoflurane or sevoflurane) at the discretion of anesthesiologist in charge of the case. A mixture of Air/O2 will be used to maintain adequate oxygenation. Nitrous oxide will not be used.

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,483 Previous Clinical Trials
485,917 Total Patients Enrolled
13 Trials studying Dementia
838 Patients Enrolled for Dementia
George Djaiani, MDPrincipal InvestigatorToronto General Hospital, University Health Network
4 Previous Clinical Trials
1,716 Total Patients Enrolled
~44 spots leftby Jun 2025
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