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Stellate Ganglion Block + Cognitive Processing Therapy for PTSD (SGB Trial)

N/A
Recruiting
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have a PTSD diagnosis verified via the Clinician Administered PTSD Scale for DSM-5
Have not previously received stellate ganglion blocks
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, on average of 3 months
Awards & highlights

SGB Trial Summary

This trial is examining whether combining Cognitive Processing Therapy with a Stellate Ganglion Block, which involves a local anesthesia injection to the neck, is more effective in reducing PTSD symptoms than CPT alone.

Who is the study for?
This trial is for adults over 18 in Illinois who have PTSD from a past traumatic event and can attend daily therapy for one week. They must speak English, have safe transport to the medical center, and not be on blood thinners or have certain health conditions like unmanaged psychosis, recent heart attack, or severe emphysema.Check my eligibility
What is being tested?
The study tests if Cognitive Processing Therapy (CPT) for PTSD works better when combined with Stellate Ganglion Block (SGB), an injection that blocks pain signals. Participants will either receive CPT + SGB or CPT + placebo in a randomized controlled trial over one week.See study design
What are the potential side effects?
Possible side effects of the Stellate Ganglion Block treatment include soreness at the injection site, light-headedness, temporary voice changes due to local anesthesia effects on vocal cords, and rare complications related to needle placement.

SGB Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with PTSD by a professional using the CAPS-5.
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I have never had a stellate ganglion block procedure.
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I am willing and able to attend daily therapy sessions for one week.
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I am 18 years old or older.

SGB Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, on average of 3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, on average of 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinician Administered PTSD Scale for DSM-5
PTSD Checklist for DSM-5 Criteria

SGB Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Stellate Ganglion BlockActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
424 Previous Clinical Trials
156,603 Total Patients Enrolled

Media Library

Stellate Ganglion Block Clinical Trial Eligibility Overview. Trial Name: NCT05534126 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Stellate Ganglion Block, Placebo
Post-Traumatic Stress Disorder Clinical Trial 2023: Stellate Ganglion Block Highlights & Side Effects. Trial Name: NCT05534126 — N/A
Stellate Ganglion Block 2023 Treatment Timeline for Medical Study. Trial Name: NCT05534126 — N/A
~89 spots leftby Oct 2026
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