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Noninvasive Neuromodulation

rTMS for Anxiety

N/A
Waitlist Available
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects must be 18-50 years old
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours
Awards & highlights

Study Summary

This trial is testing whether transcranial magnetic stimulation can help to identify the key neural mechanisms that cause anxiety, in order to develop better treatments for it.

Who is the study for?
This trial is for individuals aged 18-50 who experience anxiety, can give consent, and are right-handed. It's not suitable for those with psychiatric disorders, suicidal thoughts, substance abuse issues, seizures or epilepsy history, metal implants or body metal that affects MRI safety, claustrophobia, CNS medications use, low IQ (<80), pregnancy or increased seizure risk.Check my eligibility
What is being tested?
The study tests the effect of rTMS (repetitive transcranial magnetic stimulation) on the right dlPFC (dorsolateral prefrontal cortex) area of the brain to alleviate cognitive symptoms of anxiety. The goal is to develop new non-drug treatments for anxiety by understanding how certain brain mechanisms work.See study design
What are the potential side effects?
rTMS may cause discomfort at the stimulation site on the scalp, headache or lightheadedness during treatment. Rarely it could induce a seizure but this is uncommon especially in individuals without a seizure history.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Anxiety Potentiated Startle during NPU
Fear Potentiated Startle during NPU
Sternberg WM accuracy
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: 10 Hz ArmExperimental Treatment1 Intervention
Subjects will receive 75, 4 second trains at 10 Hz, separated by a 36 second ITI. Stimulation will occur while subjects are doing the Sternberg WM paradigm. The timing of the Sternberg task will be jittered so that each rTMS train will be administered during the maintenance interval of a WM trial.
Group II: 1 Hz ArmExperimental Treatment1 Intervention
Subjects will receive a continuous train of 1 Hz stimulation until all 3000 pulses are delivered. Consistent with the 10 Hz condition, TMS will occur during the Sternberg WM paradigm.

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Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,015 Previous Clinical Trials
42,873,963 Total Patients Enrolled
~2 spots leftby Aug 2024
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