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High Oleic Acid/Low Palmitic Acid Diet (HOA) for Aging

N/A
Recruiting
Led By Julie Dumas, Ph.D.
Research Sponsored by University of Vermont
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
"Healthy" (body mass index (BMI) of 20-40 kg/m2)
Men and women age range 65-75 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 7 days of each diet
Awards & highlights

Study Summary

This trial will study how different types of fats in the diet affect brain functioning in healthy adults aged 65-75 years. Participants will be given two different diets, one with a high ratio of pal

Who is the study for?
This trial is for healthy older adults aged 65-75 who want to participate in a study on how different fats in the diet affect brain function. Participants will follow strict diets provided by the research team and be closely monitored.Check my eligibility
What is being tested?
The study tests two diets: one high in palmitic acid, like a typical North American diet, and another high in oleic acid, similar to the Mediterranean Diet. Each participant tries both for one week with a low-fat control diet before each test period.See study design
What are the potential side effects?
Since this trial involves dietary changes rather than medication, side effects may include digestive discomfort or changes in energy levels as the body adjusts to new types of fat intake.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My BMI is between 20 and 40.
Select...
I am between 65 and 75 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 7 days of each diet
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 7 days of each diet for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Working Memory Brain Activation
Working Memory Brain Functional Connectivity
Working Memory Performance

Trial Design

2Treatment groups
Experimental Treatment
Group I: High Palmitic Acid Diet (HPA)Experimental Treatment1 Intervention
Participants will ingest the HPA diet for one week. The saturated fatty acid will be high in palmitic acid which is the most prevalent saturated fatty acid in the American diet. The HPA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.
Group II: High Oleic Acid/Low Palmitic Acid Diet (HOA)Experimental Treatment1 Intervention
Participants will ingest the HOA diet for one week. The monounsaturated fatty acid will be high in oleic acid which is the most prevalent monounsaturated fatty acid in the Mediterranean diet. The HOA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.

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Who is running the clinical trial?

University of VermontLead Sponsor
272 Previous Clinical Trials
3,743,805 Total Patients Enrolled
1 Trials studying Aging
120 Patients Enrolled for Aging
Julie Dumas, Ph.D.Principal InvestigatorUniversity of Vermont
Craig L Kien, MD, PhDPrincipal InvestigatorUniversity of Vermont
~40 spots leftby Jul 2028
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