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Opioid Agonist/Antagonist
Buprenorphine/Naloxone for Postoperative Pain
Phase 4
Waitlist Available
Led By Yi Zhang, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 6 days
Awards & highlights
Study Summary
This trial looks at whether buprenorphine/naloxone (bup/nx) can help manage postoperative pain in people who have developed a tolerance to opioids.
Eligible Conditions
- Postoperative Pain
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, an average of 6 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 6 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Length of Hospital Stay
Postoperative Opioid Consumption
Postoperative Pain Scores
Trial Design
2Treatment groups
Active Control
Group I: Buprenorphine/NaloxoneActive Control1 Intervention
Subjects will take a maximum dose of 4 mg buprenorphine and 1 mg naloxone with concurrent administration of other intravenous or oral opioids needed.
Group II: Standard Medication RegimentActive Control1 Intervention
Subjects will take conventional intravenous or oral opioid management.
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Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,943 Previous Clinical Trials
13,200,929 Total Patients Enrolled
3 Trials studying Postoperative Pain
260 Patients Enrolled for Postoperative Pain
Yi Zhang, MD, PhDPrincipal InvestigatorMassachusetts General Hospital
1 Previous Clinical Trials
23 Total Patients Enrolled
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