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Anticoagulant
Ticagrelor first for Heart Attack (DEFINE CCS Trial)
Phase 4
Recruiting
Research Sponsored by Nova Scotia Health Authority
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 days
Awards & highlights
DEFINE CCS Trial Summary
This trial will compare two drug treatments in heart attack survivors to see which one has fewer risks of bleeding/clotting. Both treatments are already approved for heart attack patients.
Eligible Conditions
- Heart Attack
- Blood Clot
DEFINE CCS Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 7 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Bleeding time
Secondary outcome measures
Differential effects on fibrin clot lysis time
Differential effects on inflammatory markers (white cell count and CRP)
DEFINE CCS Trial Design
2Treatment groups
Active Control
Group I: Ticagrelor firstActive Control2 Interventions
Patients will be treated with ticagrelor 60 mg twice a day for one week then on Day 21, will be treated with rivaroxaban 2.5 mg twice a day for one week.
Group II: Rivaroxaban firstActive Control2 Interventions
Patients will be treated with rivaroxaban 2.5 mg twice a day for one week then on Day 21, will be treated with ticagrelor 60 mg twice a day for one week.
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Who is running the clinical trial?
Nova Scotia Health AuthorityLead Sponsor
263 Previous Clinical Trials
84,916 Total Patients Enrolled
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