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Neuroprotectant

Nerinetide (NA-1) for Stroke (FRONTIER Trial)

Phase 3
Waitlist Available
Led By Jim Christenson, M.D.
Research Sponsored by NoNO Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

FRONTIER Trial Summary

This trial will test whether nerinetide can help people with acute cerebral ischemia if given soon after symptoms start.

Eligible Conditions
  • Stroke

FRONTIER Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Modified Rankin Scale (mRS) scale
Secondary outcome measures
Barthel Index
Mortality rate
National Institutes of Health Stroke Scale (NIHSS)
+2 more

FRONTIER Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Nerinetide (NA-1)Experimental Treatment1 Intervention
2.60 mg/kg of nerinetide (up to a maximum dose of 270 mg) administered as a single 10 minute IV infusion using an ambulatory infusion pump early after stroke symptom onset.
Group II: PlaceboPlacebo Group1 Intervention
Placebo administered as a single 10 minute IV infusion using an ambulatory infusion pump early after stroke symptom onset.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nerinetide (NA-1)
2015
Completed Phase 3
~540

Find a Location

Who is running the clinical trial?

NoNO Inc.Lead Sponsor
6 Previous Clinical Trials
2,823 Total Patients Enrolled
4 Trials studying Stroke
2,740 Patients Enrolled for Stroke
Brain CanadaOTHER
18 Previous Clinical Trials
5,468 Total Patients Enrolled
3 Trials studying Stroke
160 Patients Enrolled for Stroke
Djavad Mowafaghian Centre for Brain HealthUNKNOWN
~52 spots leftby Jun 2025
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