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Pioglitazone 30 mg for Insulin Resistance

Phase 2
Waitlist Available
Research Sponsored by St. Louis University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial looks at whether giving the drug pioglitazone to men with prostate cancer who are also on ADT will help improve insulin resistance.

Eligible Conditions
  • Insulin Resistance
  • Prostate Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
insulin sensitivity
Secondary outcome measures
Insulin signaling (Insulin receptor substrate expression in fat tissue)

Side effects data

From 2013 Phase 3 trial • 936 Patients • NCT01183013
10%
Oedema peripheral
9%
Hypertension
9%
Back pain
7%
Nasopharyngitis
7%
Hyperglycaemia
5%
Urinary tract infection
5%
Headache
4%
Pain in extremity
4%
Bronchitis
3%
Oedema
2%
Diarrhoea
2%
Arthralgia
2%
Upper respiratory tract infection
1%
Pneumothorax
1%
Pancreatitis acute
1%
Rectosigmoid cancer
1%
Hairy cell leukaemia
1%
Jaundice
1%
Myocardial infarction
1%
Intestinal haemorrhage
1%
Pneumonia
1%
Small intestine carcinoma
1%
Bipolar disorder
1%
Intervertebral disc protrusion
100%
80%
60%
40%
20%
0%
Study treatment Arm
Pio15/Pio30
Pio30/Pio30
Pio45/Pio45
Lina5/Lina5
Lina5Pio15/Lina5Pio30
Lina5Pio30/Lina5Pio30
Lina5Pio45/Lina5Pio45

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: PioglitazoneExperimental Treatment1 Intervention
Group II: placeboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pioglitazone 30 mg
2021
Completed Phase 4
~1670

Find a Location

Who is running the clinical trial?

St. Louis UniversityLead Sponsor
194 Previous Clinical Trials
43,655 Total Patients Enrolled
1 Trials studying Insulin Resistance
~0 spots leftby Jun 2025
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