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Mirvetuximab + Bevacizumab for Ovarian Cancer
Study Summary
This trialtests a new drug for advanced ovarian, peritoneal, or fallopian cancers with high FRα expression.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I agree to use effective birth control methods if I can have children.I have mild to severe numbness, tingling, or pain in my hands or feet.I cannot start treatment with a high dose of bevacizumab.I received a dose of bevacizumab after my last triplet therapy before being assigned to a treatment group.I have had severe blood clotting issues in the past.I have brain metastases that are either untreated or causing symptoms.I have a serious heart condition.My condition worsened while on or after platinum-based cancer treatment.I have a history of multiple sclerosis or similar conditions.My blood, liver, and kidney functions are all within normal ranges.I do not have any serious illnesses or active infections.I have a history of liver cirrhosis.I am not pregnant or breastfeeding.I have been diagnosed with a specific type of ovarian, peritoneal, or fallopian tube cancer.I have recovered from side effects of previous cancer treatments.I am suitable for, currently on, or have finished a specific cancer treatment involving platinum.I am fully active or restricted in physically strenuous activity but can do light work.I have ongoing eye conditions needing treatment or a history of corneal issues.My cancer has responded or remained stable with second-line treatment.I am 18 years old or older.I have had issues with my bowels, like blockages or infections.I have been diagnosed with a type of lung disease not caused by infection.I have had a stroke in the last 6 months.My ovarian cancer is of a specific type, such as endometrioid or clear cell.My cancer returned after one platinum-based treatment and responds to platinum.I have had more than one chemotherapy treatment before my current or planned therapy.I've had extensive radiation therapy affecting a lot of my bone marrow.I have had BRCA testing done on my tumor or through a blood test.I have previously been treated with MIRV or drugs targeting FRα.I have had another type of cancer within the last 3 years.I've had 4 to 8 rounds of a specific chemotherapy for my cancer.I had my last major surgery more than 4 weeks ago.
- Group 1: Arm 1
- Group 2: Arm 2
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants have been recruited for this clinical assessment?
"Indeed, the online clinicaltrials.gov registry reveals that this trial is presently accepting patients. It was first advertised on November 1st 2022 and has been recently updated on 11/9/2022. This research project needs 418 participants from a single site to be recruited."
Is Arm 1 of the study proven to be innocuous for participants?
"Arm 1 is rated as a 3 on a scale of safety, due to the fact that data demonstrating efficacy has been collected and multiple rounds of evidence supporting its security have been procured."
Is this research project currently enrolling participants?
"Data housed on clinicaltrials.gov affirms that this medical trial is actively enrolling volunteers. The study was initially advertised on November 1st 2022 and last modified nine days later."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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