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Corticosteroid

Bupivacaine/triamcinolone injection for Cough

Phase 3
Recruiting
Research Sponsored by University of South Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediately pre-treatment and post-treatment at 2 weeks
Awards & highlights

Study Summary

This study is evaluating whether a specific injection may help reduce coughing in individuals with neurogenic cough.

Eligible Conditions
  • Cough
  • Caudal Epidural Block Therapy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediately pre-treatment and post-treatment at 2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately pre-treatment and post-treatment at 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
2 week post-treatment cough severity index score improvement
2 week post-treatment cough-specific quality-of-life questionnaire score improvement
Secondary outcome measures
12 week post-treatment cough severity index score improvement
12 week post-treatment cough-specific quality-of-life questionnaire score improvement
6 week post-treatment cough severity index score improvement
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Bupivacaine/triamcinolone injectionExperimental Treatment1 Intervention
2-cc injection (mixture consisting of 1-cc of 0.5% Bupivacaine injection and 1cc of 40mg/cc triamcinolone acetonide suspension injection) will be delivered percutaneously into the region of the proximal superior laryngeal nerve, every 1-2 weeks, for total of 2 to 3 injections
Group II: Saline injectionPlacebo Group1 Intervention
2-cc injection of normal saline will be delivered percutaneously into the region of the proximal superior laryngeal nerve, every 1-2 weeks, for total of 2 to 3 injections

Find a Location

Who is running the clinical trial?

University of South FloridaLead Sponsor
414 Previous Clinical Trials
188,232 Total Patients Enrolled
~15 spots leftby Jun 2025
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