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Checkpoint Inhibitor

Axitinib for Adenoid Cystic Carcinoma

Phase 2
Waitlist Available
Led By Renata Ferrarotto
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 years
Awards & highlights

Study Summary

This trial studies the combo of axitinib & avelumab to see if it can better control adenoid cystic carcinoma than axitinib alone.

Eligible Conditions
  • Adenoid Cystic Carcinoma
  • Progressive Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall response rate
Secondary outcome measures
Duration of response
Incidence of adverse events
Overall survival
+1 more

Side effects data

From 2019 Phase 2 trial • 13 Patients • NCT02129647
30%
Mucositis
10%
Fatigue
10%
Rash
10%
nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Axitinib

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (axitinib, avelumab)Experimental Treatment2 Interventions
Patients receive axitinib PO BID on days 1-28 and avelumab IV over 1 hour on days 1 and 15. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Axitinib
FDA approved
Avelumab
FDA approved

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,986 Previous Clinical Trials
1,789,478 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,717 Previous Clinical Trials
40,953,328 Total Patients Enrolled
Renata FerrarottoPrincipal InvestigatorM.D. Anderson Cancer Center
6 Previous Clinical Trials
133 Total Patients Enrolled
~6 spots leftby May 2025
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