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Antibiotic

Low Dose Rifaximin DER for Sickle Cell Disease

Phase 2
Waitlist Available
Research Sponsored by Bausch Health Americas, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 29
Awards & highlights

Study Summary

This trial is testing a new drug for sickle cell disease. 60 people will be enrolled, half taking the new drug and half taking a placebo. The trial will last for 3 months.

Eligible Conditions
  • Sickle Cell Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 29
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 29 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum plasma concentration

Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: Low Dose Rifaximin ERExperimental Treatment1 Intervention
twice daily
Group II: Low Dose Rifaximin DERExperimental Treatment1 Intervention
twice daily
Group III: High Dose Rifaximin ERExperimental Treatment1 Intervention
twice daily
Group IV: High Dose Rifaximin DERExperimental Treatment1 Intervention
twice daily
Group V: PlaceboPlacebo Group1 Intervention
twice daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High Dose Rifaximin DER
2022
Completed Phase 2
~50
Low Dose Rifaximin ER
2022
Completed Phase 2
~50
Low Dose Rifaximin DER
2022
Completed Phase 2
~50
High Dose Rifaximin ER
2022
Completed Phase 2
~50

Find a Location

Who is running the clinical trial?

Bausch Health Americas, Inc.Lead Sponsor
262 Previous Clinical Trials
81,984 Total Patients Enrolled
Anya LoncaricStudy DirectorBausch Health
39 Previous Clinical Trials
20,787 Total Patients Enrolled
Varsha BhattStudy DirectorBausch Health
8 Previous Clinical Trials
995 Total Patients Enrolled
~14 spots leftby Jun 2025
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