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Muscarinic Receptor Antagonist

CVL-231 for Schizophrenia

Phase 1
Waitlist Available
Research Sponsored by Cerevel Therapeutics, LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up screening, day-1 (t=1hour), day-1 (t=1.5hour), day-1, day 1 (t=0hour), day 1(t=1.5hour), day 1 (t=3hour), day 1 (t=6hr), day 1 (t=8.0), day 2 (t-=24hr), day 10
Awards & highlights

Study Summary

This trial will test how well a new drug called CVL-231 binds to muscarinic receptors type 4 in the brain, after it is taken by mouth.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~screening, day-1 (t=1hour), day-1 (t=1.5hour), day-1, day 1 (t=0hour), day 1(t=1.5hour), day 1 (t=3hour), day 1 (t=6hr), day 1 (t=8.0), day 2 (t-=24hr), day 10
This trial's timeline: 3 weeks for screening, Varies for treatment, and screening, day-1 (t=1hour), day-1 (t=1.5hour), day-1, day 1 (t=0hour), day 1(t=1.5hour), day 1 (t=3hour), day 1 (t=6hr), day 1 (t=8.0), day 2 (t-=24hr), day 10 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
M4 receptor occupancy in the striatum following single oral doses of CVL-231 in healthy adult subjects
Secondary outcome measures
AUCscan duration for CVL-231
Cavg/Scan duration for CVL-231
Cmax during scan for CVL-231
+7 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: CVL-231Experimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CVL-231
2022
Completed Phase 1
~300

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Cerevel Therapeutics, LLCLead Sponsor
35 Previous Clinical Trials
5,704 Total Patients Enrolled
7 Trials studying Schizophrenia
2,011 Patients Enrolled for Schizophrenia
Matthew Leoni, MD, MBAStudy DirectorCerevel Therapeutics, LLC
2 Previous Clinical Trials
89 Total Patients Enrolled
1 Trials studying Schizophrenia
16 Patients Enrolled for Schizophrenia
~4 spots leftby Jun 2025
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