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Cancer-treated patients receiving NIRFLI for Lymphedema

Phase 1
Waitlist Available
Led By Melissa B Aldrich, PhD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months after radiation
Awards & highlights

Study Summary

This trialaims to uncover how LE develops, so treatments can be developed to target its underlying causes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months after radiation
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months after radiation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Lymphatic propulsive frequency as assessed by NIRFLI
Lymphatic propulsive velocity as assessed by NIRFLI
Percent extravascular dye as assessed by NIRFLI
+2 more
Secondary outcome measures
Chemokine levels as assessed by bead assay
Cytokine
Number of participants with autoimmune antibodies as assessed by ELISA

Trial Design

1Treatment groups
Experimental Treatment
Group I: Cancer-treated patients receiving NIRFLIExperimental Treatment2 Interventions
Near-infrared Fluorescence Lymphatic Imaging (NIRFLI) using Indocyanine Green (ICG) is used to "visualize" lymphatic vessel anatomy and function.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Indocyanine green
FDA approved
Near-infrared Fluorescence Lymphatic Imaging (NIRFLI)
2017
Completed Phase 1
~80

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
912 Previous Clinical Trials
323,642 Total Patients Enrolled
2 Trials studying Lymphedema
303 Patients Enrolled for Lymphedema
M.D. Anderson Cancer CenterOTHER
2,987 Previous Clinical Trials
1,798,155 Total Patients Enrolled
3 Trials studying Lymphedema
610 Patients Enrolled for Lymphedema
National Cancer Institute (NCI)NIH
13,717 Previous Clinical Trials
40,953,234 Total Patients Enrolled
31 Trials studying Lymphedema
14,250 Patients Enrolled for Lymphedema
~10 spots leftby Jun 2025
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