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Unknown

Treatment sequence B-A for High Cholesterol

Phase 1
Waitlist Available
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose
Awards & highlights

Study Summary

This trial studies how a new drug (AZD0780) interacts with an existing drug (rosuvastatin) and how safe it is when taken alone or together.

Eligible Conditions
  • High Cholesterol

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Apparent total body clearance (CL/F) of AZD0780
Apparent total body clearance (CL/F) of Rosuvastatin
Apparent volume of distribution during the terminal phase after extravascular administration (Vz/F) of AZD0780
+11 more
Secondary outcome measures
Number of participants with Adverse Events

Trial Design

2Treatment groups
Experimental Treatment
Group I: Treatment sequence B-AExperimental Treatment2 Interventions
Participants will receive 1 treatment during each study period in the following sequence: a single dose of rosuvastatin tablet + AZD0780 tablet (Treatment B) in period 1 and then a single dose of rosuvastatin tablet alone (Treatment A) in period 2.
Group II: Treatment sequence A-BExperimental Treatment2 Interventions
Participants will receive treatments in the following sequence, a single dose of rosuvastatin tablet alone (Treatment A) in period 1, and then a single dose of rosuvastatin tablet + Dose X AZD0780 tablet (Treatment B) in period 2.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AZD0780
2023
Completed Phase 1
~20
Rosuvastatin
2019
Completed Phase 4
~3150

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,286 Previous Clinical Trials
288,620,034 Total Patients Enrolled
9 Trials studying High Cholesterol
11,022 Patients Enrolled for High Cholesterol
~7 spots leftby Jun 2025
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