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Phosphodiesterase 4 Inhibitor

Roflumilast for Asthma

Phase 1
Waitlist Available
Led By Nicholas Kenyon, MD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial will test whether or not roflumilast can help asthmatics who are obese and have low levels of a certain receptor respond better to β2 adrenoreceptor agonists.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Beta 2 Agonist response from Baseline
Secondary outcome measures
Asthma Control Test score
Exhaled nitric oxide

Side effects data

From 2015 Phase 4 trial • 12 Patients • NCT03073798
8%
Pulmonary Exacerbation
100%
80%
60%
40%
20%
0%
Study treatment Arm
All Participants

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: RoflumilastExperimental Treatment1 Intervention
Roflumilast 500mcg by mouth, once daily, for 70 days (10 weeks).
Group II: PlaceboPlacebo Group1 Intervention
Placebo by mouth, once daily, for 70 days (10 weeks).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Roflumilast
2013
Completed Phase 4
~9010

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of California, DavisLead Sponsor
914 Previous Clinical Trials
4,720,710 Total Patients Enrolled
7 Trials studying Asthma
350 Patients Enrolled for Asthma
Nicholas Kenyon, MDPrincipal InvestigatorUniversity of California, Davis
2 Previous Clinical Trials
50 Total Patients Enrolled
2 Trials studying Asthma
50 Patients Enrolled for Asthma
~1 spots leftby Jun 2025
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